The Amazing Spider-Man 6 is the sequel to The Amazing Spider-Man 5.
Aunt May becomes severely sick and goes to the hospital. Wilson Fisk gives Dr. Farley Stillwell money to create the Scorpion treatment and suit. He gives it to Fisk's friend Mac Gargan and Gargan becomes the Scorpion. Stillwell, who is really a nice person, kills himself trying to stop the Scorpion by trying to give him an antidote before he because truly insane. Fisk orders him to destroy Spider-Man because he stopped all of their last robbery plans. The Black Cat meanwhile robs a bank, but Spider-Man stops her and she leaves. Chameleon learns Spider-Man's identity. He then tells Scorpion who attacks Parker at his house. He gets taken to Fisk who tortures him. Black Cat then appears and saves Parker. Both of them leave and Black Cat explains to him how she became the Black Cat. The world now knows that Peter Parker is Spider-Man, but he doesn't want Aunt May to know, who is in a coma. Scorpion then battles Spider-Man in the end, with Spider-Man barely winning. Aunt May then passes away in the end, leaving Peter very sad. Before she died, Peter told her he was Spider-Man. Chameleon then brings Kraven the Hunter over from Africa to face off against Spider-Man. Spider-Man wins, but Scorpion nearly kills him after coming out of nowhere. Black Cat then comes and stops Scorpion and Spider-Man finishes him off and brings him to jail. Black Cat and Spider-Man fall in love, but Mary Jane sees Spider-Man with her and leaves him. At the end of the movie, a man named The Rose comes up to Fisk and tells him he has a plan. The Symbiote is then seen changing in the OSCORP Building.
- Nick Palatas as Peter Parker/Spider-Man
- Laura Vandervoort as Felicia Hardy/Black Cat
- Channing Tatum as Mac Gargan/Scorpion
- Minka Kelly as Mary Jane Watson
- Michael Massee as Dmitri Smerdyako/Chameleon
- Tom Selleck as Kraven the Hunter
- James Gandolfini as Wilson Fisk
- Zac Efron as Harry Osborn
- Josh Stewart as Mysterio Mercenary/Lyon Kramer
- Matt Levin as Dr. Farley Stillwell
- Eric Roberts as Luchino Nefaria
- Sally Field as May Parker
- Joe Grifasi as Walter Hardy/The Cat
- Jason Lee as Frederick Foswell/Patch
- Irrfan Khan as Dr. Rajit Ratha
- Samuel L. Jackson as Nick Fury (cameo)
- Robert de Niro as The Rose (cameo)
- Maximiliano Hernandez as Jasper Sitwell (cameo)
The sequel will be called The Ultimate Spider-Man and will feature the Sinister Six.