A reboot of a full-scale Spider-Man series.
1st installment: The Amazing Spider-Man (2012)
Peter Parker tries to discover the truth about his parents, when he faces the Lizard.
2nd installment: Web of Spider-Man(2014)
Peter goes up against the Green Goblin.
3rd installment: Web of Shadows (2017)
Peter, upon being depressed that Gwen has died at the hands of the Green Goblin, Harry discovers Norman Osborn's lab of spider serums, and a symbiotic ooze escapes from SHIELD, and Harry uses the last one of Peter's Spider DNA samples to merge it with the symbiote to make as his own, turning him into Venom. But when Nick Fury warns Peter that the symbiote is corrupting Harry, he must act fast to save his best friend and admit that he is sorry for killing his father.
4th and final installment: The Spectacular Spider-Man (2019)
Peter realizes that Norman Osborn had Miles Warren use DNA of Spider-Man to make a clone army, and now Spider-Man must end this and save all of humanity, and even becoming more romantic with Mary Jane Watson by proposing to her.
Frank Castle (2014)
Frank Caslte was sent by Miles Warren to target Spider-Man, believing him to be Gwen Stacy's killer, but he gets attacked by Miles Warren.
A woman naked with Peter's DNA during the events of Web of Spider-Man, was trained by HYDRA under Taskmaster and Baron Strucker's cares, but escapes and adopted the identity of Jessica Drew, but when HYDRA seek to re-capture her.
- Peter Parker/Spider-Man (Andrew Garfield)
- Mary Jane Watson (Megan Fox)
- Gwen Stacy (Emma Stone)
- Nick Fury (Samuel L. Jackson)
- May Parker (Sally Field)
- J. Jonah Jameson (Brian-Dole Murray)
- Betty Brant (???)
- Robbie Robertson (Morgan Freeman)
- Captain George Stacy (Denis Leary)
- Curt Connors/Lizard (Rhys Ifan) - main antagonist of The Amazing Spider-Man
- Norman Osborn/Green Goblin (Dennis Quaid) - main antagonist of Web of Spider-Man
- Harry Osborn/Venom (Joseph Gordon-Levitt/Fred Tatasciore) - main antagonist of Web of Shadows, later reforms.
- Miles Warren/Jackal (Michael Masse) - main antagonist of Frank Caslte and The Spectacular Spider-Man
- Maxwell Dillion/Electro (Leif Gantvoort) - the secondary antagonist of The Spectacular Spider-Man
- Baron Wolfgang Von Strucker (Arnold Vosloo) - main antagonist of Spider-Woman