Mojo Jojo has send the Powerpuff Girls to the future and he rule the world, thanks to apes and monkeys army.
This is the movie Mojo Jojo will win in the future and gets defeated both present and future for the finall time.
- Powerpuff Girls
- Mojo Jojo: A evil master mind chimpanzee and former assistant to the Prof.Utonium, has finally won by sending the Powerpuff Girls to the future by mistake and re-named "King Mojo."
- Mojo Jojo's Prime 8s: Genetic alter simians that serves as his generals, they don't brains pop out of their skulls (Mojo learns that cause more problems for him) and DC and Marvel villains.
- Bad Goon: A genetic baboon with the same strenght as Buttercup and actual defeats her. He is biker and a fan of Rock'N'Roll music, his weapon is electric guitar and metal teeth.
- Sparky: A living electrical monkey that control and create shock blast, known to be Mojo Jojo's favorite and love to party.
- Parrotkey Flo (voiced by Ester Dean): A half parrot and half monkey, a very proud singer that rules Rio and becomes friends with Bubbles because she like dancing in air and on floor.
- Parrotkey: Her people and worshippers.
- Gorgo: A monster-sized gorilla and Flo's rival.
- Multi Chimp
- Hota Wata
- Bitsy Spidress
- Stinger (voiced by Dee Bradely Baker): A scorpion monkey and Bitsy Spidress' boyfriend.
- Cobra Queen: A vampire that trap in a form of a red cobra and made deal with Mojo Jojo to rule the world together. She has power drain the youth of her prey and retain her beauty, Mojo Jojo fell for her because she is so evil and don't care she a snake.