With the Loonatics as Guardians of the Universe, and Zadavia and Optimatus as rulers of Freeling, Ace, Lexi, Danger, Slam, Tech and Rev travel to new dimensions, but when on Earth in Acmetropolis, it has become a frozen winterland, and there are breakouts of the police, and the public is turned against the Loonatics for not coming back that long, and a new evil has awaken. They has a new friend named Kamo on the team.
Heroes of Acmetropolis, and the guardians of the universe.
- Ace Bunny (Charlie Schlatter) - according to his file being downloaded by Rupes Oberon, he was born 12/12/54, he was a stunt actor, and when he gained his abilities quit the stunt acting!, he is currently age 18 in 2772
- Lexi Bunny (Jessica DiCicco) - according to her file being downloaded by Rupes Oberon, she was born 12/29/55, she was a runner for cherrleading, and when she gained her powers she proved to be better!, she is currently age 17 in 2772
- Danger Duck (Jason Marsden) - according to his file being downloaded by Rupes Oberon, he was born 1/15/55, he was adopted, and when he gained his abilites actually scared the bullies away! he is currently age 17 in 2772
- Slam Tasmanian (Kevin Michael Richardson) - according to his file being downloaded by Rupes Oberon, he was born 6/31/50, he was in a wresting match and was a one they'd hope to lose but instead got better!, he is currently age 22 in 2772
- Tech E. Coyote (Kevin Michael Richardson) - according to his file being downloaded by Rupes Oberon, he was born 5/10/55, he was always the one who is disregarded, now is regarded thanks to his powers , he is currently age18 in 2772
- Rev Runner (Rob Paulsen) - according to his file being downloaded by Rupes Oberon, he was born 5/20/53, he was cheated on the job, and time, and now throws his shoes away cause of his new power, he is currently age 17 in 2772
- Kamo Iggmar (Nolan North) - A new member wearing blue, before joing the team, he was born 9/1/53, he is training to be a soldier, and now a hero, he is currently age 19 in 2772.
- Royal Tweetums (Joe Alaskey)
- Zadavia (Candi Milo)
- Optimatus (Charlie Adler)
- Acmetropolis police officer Sandy White (Christina Applegate) - A police officer of Acmetropolis Police Department
- Drake Sypher (Phil LaMarr) - Has learned to use his powers to absorb the properties of anything he touches, He was destroyed by the Shadow and drains him of his powers.
- Agmartis Iggmar (Brad Abrell) - Kamo's father, begs his son for forgiveness.
- Weathervane (Kaley Cuoco)
- Time Skip (David Faustino)
- Rupes Oberon/Keybord Man (Jason Marsden) - helped free Sypher, Weathervane and Time Skip, he snuck into the Loonatics' former headquarters to steal information about their origins, and realizes that their headquarters was built from the remains of an Alien Ship, which was previously owned by Zadavia, and that their costumes came from the matter of the energy of the meteroid!
- Mastermind (Florence Henderson)
- Massive (Kevin Michael Richardson)
- General Deuce (Khary Payton) - forms an alliance with Weathervane, Sypher, Massive, Mastermind and Time Skip to compete against the Loonatics, he has them steal ??? to make a portal to go ???, which unknown to them, Deuce was used into summoning the Shadow
- Gooboid (Dee Bradley Baker) - A Slime beast that was accidently released by Slam.
- Iron-Bull (Michael Dorn) - a descendent of the bull Bugs dealt with centuroes ago!
- The Shadow (Kevin Grievoux) - one of the 2 main antagonists, he was once a being of Pure energy until was corrupted by a Blackhole, he was accidentally released by Zadavia, and corrupted Optimatus, his goal is to take over the Galaxy, and bend the balance of Nature.
- Adolpho (Mark Hamill)
- Red (Olivia d'Abo) - a Siren, whom is similar to Red on the Tex Avery cartoons!
- Lupes Reeps (Ted Biaselli) - a loudmouth, antagonizing reporter, who is head of the Silly Station Show, who antagonizes the Loonatics for not coming back on Earth and sees them as animal dangers to the public, He is exposed as a Dodo/ Googoo, and was arrested for helping Iron Bull.
- Kamo-Bot - a robot created by Mastermind to frame the real Kamo
- Hassan the Assassin (Maurice LaMarche)
- Otto the Odd (Dee Bradley Baker) - replaces Sypher, as they plan to take vengeance on the Loonatics.
- Gogoagoogoo (Brendan O'Brien) - the first enemy the Loonatics fought
- Melvin the Martian (Joe Alaskey)
- Black Velvet (Vivica A. Fox) - serves as a herald to Shadow after he rescued her
- Android: 55 - The First creation of Zadavia until it went rogue.
- Umpas (John DeLancie)
- Speedy Gonzales the IIV (Carlos Alazraqui)
- Lord Repananamus (Chris Cox) - Zadavia's son, one of the 2 main antagonists
|27||Waves of Change||Weathervane, Adolpho||The Loonatics must stop an escaped Adolpho and Weathervane from causing another Great Flood!|
|28||Sleepless Wonder||Red||Red, a singer with powers of the Siren, can charm any man or Male Loonatic, so it's up to Lexi and a tone deaf Tech to save them!|
|29||A New Lizard in Town||Agmartis||An army of cybernetic reptiles,led by Agmartis, wreaks havoc in the city. Kamo must betray his father and help the Loonatics save Acmetropolis.|
Kamo is the newest member of the Loonatics. But some immature members say he's not a member until he passes the "initiation."
|31||Date Night||Iron Bull||The day finally arrives. Ace is taking Lexi out on a date. Ace was about to confess his feelings to her. Until, a giant anthro bull ambushes them.|
|32||Danger's Birthday||Sypher||It's Duck's birthday and the Loonatics are going on a trip.|
|33||Looming Shadow, Part 1||The Shadow||Zadavia confesses that She accidently released the Shadow that corupted Optimatus, and Tech admitted he cheated the Bet with Danger Duck.|
|34||Looming Shadow, Part 2||The Shadow||They learn that the Shadow destroyed Sypher,and is now an alien leach.|
|35||Into the Dunes||Hassan the Assassan||Slam and Tech are placed a bounty by Pinkster, and Duck and Ace face their ancestors secrets.|
|36||Enter the Madness||Otto the Odd||Otto the Odd has caused the whole Acmetopolis to become a topsy turvy world, and Lexi and Ace are the only ones to stop him.|
|37||Reptile Behind Bars||Mastermind|
|There were multiple arsons that've been happening lately and culprit was Kamo. He was put to jail. The Loonatics refuses to believe that he commited those crimes as they will have to find out who framed him.|
|38||Mad Men General||General Deuce||Deuce return for revenge against the Loonatics when he mind control Agmartis's army. When the Loonatics were almost destroyed by a ambush, Agmartis saved them and ask to help and ask his son to forgive him. The Loonatics are thinking about trusting him.|
|39||The Origin of Loonatics||Gogoagoogoo||Discover the true origins of their past lives, how they became heroes, and why they were recruited by Zadavia.|
|40||Duck Danger's of 29th and a half century.||Melvin the Martian||Tired of being treated like a fool, Danger Duck quits the Loonatics and begins a space adventure of his own, he becomes Duck Dangers, but things get worse when he must stop Melvin the Martian from blowing up earth.|
|41||Black Voice of the Shadow||Black Velvet, The Shadow.||The Shadow rescues the Black Velvet from the light, and gives her a task to Capture the Sound of Red Siren.|
|42||Tech, Rev, Ace, Danger, Slam, and Lexi: All Star Story||Android: 55||the gang apologizes to Duck, and Kamo is the only one who can rescue them.|
|43||Storm Mountain||Weathervane, Massive, Otto the Odd, and Mastermind||Otto the Odd replaces Sypher, and they make a mountain base and they plan to destroy the Loonatics.|
|44||Enter Umpas||Umpas||Umpas a Troll whom is collecting intergalactic beings for his personal collection, and Tech is his target.|
|45||Speedy Gonzales the IIV||Gonzales||Rev is framed by Speedy, and Tech helps clear is name even if he has to go undercover at Gonzales's club.|
|46||Lexidavia||Lord Repananamus||Lexi and Zadavia merge into one and learn each other's past, and Lexi ultimately realizes Zadavia has a son Repananamus|
|47||Checkmate||General Deuce, Otto the Odd||Deuce and Otto play chess with The Loonatics as the pawns, and the Aliens as the game pieces, and Slam is the only one with the will to save them.|
|48||Rays of Light||The Shadow||The Shadow tries to steal the Rays of Light, so that The Loonatics wouldn't have the advantage.|
|49||Demotion||Adolpho, Massive||Ace is demoted for his arrogance, and for his lack of humility, and Duck takes control, bites off more than he can chew.|
|50||Return of Dr. Dare||Dr. Dare||Dr. Dare is released again, and he wants the team defeated once and for all time.|
|51||Eternal Night, Part 1||The Shadow||The Shadow plans to create an eternal night in Achmetropolis, and the Loonatics must use the Rays of Light to bring back the day.|
|52||Eternal Universe, Part 2||Lord Repananamus||After the Shadows Defeat Lord Repananamus must be stopped or he will marry Lexi and rule the galaxy.|