- Sora (Haley Joel Osment) - The key that connects everything. The Leader of the 7 Lights
- Riku (David Gallagher) - The fallen friend who's finally achieved redemption through becominbg a Keyblade Master. One of the 7 Guardians of Light.
- Kairi (Hayden Panettiere) - The true love that will not let worlds keep them apart. One of the 7 Lights.
- Donald (Tony Anselmo) - The short tempered royal magician.
- Goofy (Bill Farmer) - The simple minded captain of the royal knights.
- King Mickey (Bret Iwan) - The once and future king who carries the burden of the universe on his shoulders. One of the 7 Lights.
- Aqua (Willa Holland) - One of the 7 Lights.
- Terra (Jason Dohring) - One of the supposed 7 Lights who was turned into Xehanort's 6th Vessel.
- Ventus (Jesse McCartney) - One of the 7 Lights.
- Lea (Quinton Flynn) - The newest keyblade wielder and his nobody Axel was a former member of Organization XIII. One of the 7 Lights.
- Elena - The reconstructed somebody of Larxene, former member of the original Organization XIII. Looking to redeem herself for all of the suffering she caused in her madness, fights by Lea's side against the Nu Organization's forces.
- Ansem the Wise (Corey Burton) - The scientest supreme whose looking to correct the consequences of his experiments.
- Max Goof (Jason Marsden) - A paladin in training, trying to step out of his father's shadow.
- Chip 'n' Dale (Tress MacNeille and Corey Burton) - Extraordinary spaceflight engineers, who don't let their size hold back their genius designs.
- Jiminy Cricket (Phil Snyder) - The conscience and scribe of world traveling heroes.
- Pluto - The king's loyal canine, who always ends up in the wrong place at the wrong time.
- P.J. (Rob Paulsen)
Disney Party Members
- Jane Darling (Harriet Owen) - Only world in Neverland.
- Stitch (Chris Sanders) - Only world in Hawaii.
- Milo Thatch (Cam Clarke) - Only world in Atlantis.
- Hercules (Tate Donovan) - Only world in Olympus Coliseum.
- Quasimodo (Ari Rubin) - Only world in La Cite Des Cloches.
- Pongo (Tom Kane) - Only world in Dalmatian London.
- Aladdin (Scott Weinger) - Only world in Agrabah.
- Tiana (Anita Noni Rose) - Only world in New Orleans.
- Kuzco (David Spade) - Only world in Kuzcotopia.
- Melody (Tara Strong)' - Only world in Atlantica.
- Jim Hawkins (Joseph Gordon-Hevitt) - Only world in Treasure Planet.
- Oliver (E. G. Daily) - Only world in New York City.
- Bob Parr/Mr. Incredible (Dan Castellaneta) - Only world in Metroville.
- Jack Sparrow (James Arnold Taylor) - Only world in Port Royal.
- Wreck-It Ralph (John C. Reilly) - Only world in Game Central Station.
- Kiara (Tara Strong) - Only world in Pride Lands.
- Bernard (Corey Burton) - Only world in City of Rescuers.
- Winnie the Pooh (Jim Cummings) - Only world in The Hundred Acre Wood.
- Peter Pan (Blayne Weaver)
- Tinker Bell
- The Octopus
- Lilo (Tara Strong)
- Nani (Tia Carrere)
- Dr. Jumba Jookida (David Ogden Stiers)
- Pleakley (Kevin McDonald)
- Kida (April Winchell)
- Vincenzo (Billy West)
- Audrey (Candi Milo)
- Gaetan (Corey Burton)
- Philoctetes (James Arnold Taylor)
- Megara (Susan Egan)
- Pegasus (Frank Welker)
- Zeus (Corey Burton)
La Cite Des Cloches
- Esmeralda (Grey DeLisle)
- Captain Phoebus (Kevin Michael Richardson)
- Clopin (Hank Azaria)
- Hugo (Jason Alexander)
- Victor (Charles Kimbrough)
- Laverne (April Winchell)
- Perdita (Kath Soucie)
- 99 Puppies
- Colonel (Jim Cummings)
- Segeant Tibbs (Tom Kenny)
- Captain (Will Ryan)
- Jasmine (Linda Larkin)
- Genie (Dan Castellaneta)
- Abu (Frank Welker)
- Iago (Gibbert Gottfried)
- Cassim (John Rhys-Davies)
- The Peddler (Corey Burton)
- Prince Naveen (Bruno Campos)
- Ray (Jim Cummings)
- Louis (Michael-Leon Wooley)
- Charlotte (Jennifer Cody)
- Pacha (Fred Tatasciore)
- Kronk (Patrick Warburton)
- Chicha (Wendie Mallck)
- Ariel (Jodi Benson)
- Prince Eric (Jeff Bennett)
- Flounder (Mark Hamill)
- Sebastian (Kevin Michael Richardson)
- King Triton (Corey Burton)
- Tip (Max Casella)
- Dash (Hank Azaria)
- John Silver (Jim Cummings)
- B.E.N. (Dan Castellaneta)
- Morph (Dane A. Davis)
- Dr. Delbert Doppler (David Hyde Pierce)
- Captain Amelia (Emma Thompson)
New York City
- Dodger (Hank Azaria)
- Rita (Grey DeLisle)
- Tito (James Arnold Taylor)
- Francis (Corey Burton)
- Einstein (Kevin Michael Richardson)
- Fagin (Maurice LaMarche)
- Jenny Foxworth (G.K. Bowes)
- Winston (Jeff Bennett)
- Helen Parr/Mrs. Incredible (Holly Hunter)
- Violet Parr (Sarah Vowell)
- Dash Parr (E. G. Daily)
- Frozone (Samuel L. Jackson)
- Will Turner (Crispin Freeman)
- Elizabeth Swann (Eliza Schneider)
- Hector Barbossa (Brian George)
- Bootstrap Bill Turner (Kelsey Grammer)
Game Central Station
- Vanellope Von Schweetz (Sarah Silverman)
- Fix-it Relix, Jr. (Jack McBrayer)
- Segeant Colhoun (Jane Lynch)
- Sonic the Hedgehog (Roger Craig Smith)
- Simba (Cam Clarke)
- Nala (Vanessa Marshall)
- Timon (Bruce Lanoll)
- Pumbaa (Ernie Sabella)
- Zazu (Rowan Atkinson)
- Kovu (Jason Marsden)
City of Rescuers
- Miss Bianca (Russi Taylor)
- Chairmouse (Corey Burton)
- Orville (Jeff Bennett)
- Penny (Tara Strong)
- Ellie Mae (G.K. Bowes)
- Luke (Maurice LaMarche)
- Wilbur (Rob Paulsen)
- Jake (Tristan Rogers)
- Cody (Adam Ryen)
- Marahute (Frank Welker)
- Faloo (Grey DeLisle)
- Cody's Mother (Grey DeLisle)
The Hundred Acre Wood
- Tigger (Jim Cummings)
- Piglet (Travis Oates)
- Rabbit (Tom Kenny)
- Eeyore (Bud Luckey)
- Kanga (Kristen Anderson-Lopez)
- Roo (Wyatt Dean Hall)
- Owl (Craig Ferguson)
- Christopher Robin (Haley Joel Osment)
- The Horned King (John Hurt) - The first demon, an agent of chaos that was born long ago in darkness, he holds control over all the Heartless and will not stop until he finds the Black Cauldron, which can turn any corpse dipped into it into an invincible zombie in hopes of taking over all worlds.
- Master Xehanort (Leonard Nimoy) - The dark keyblade master longing to obtain the power of Kingdom Hearts, but his quest to do so has been the cause for all the misery and devastation in the worlds for decades. His plan to restart the Keyblade War with his 13 darknesses has been helped along by his ally, the Horned King.
- Young Xehanort (Benjamin Diskin) - The younger incarnation of Xehanort that has come from the past to join his current self, Young Xehanort is a deadly opponent who's powers over time and space have allowed him to recruit many villains towards the Horned King's goal.
- Ansem, Seeker of Darkness (Billy Zane) - Xehanort's heartless who once faced off against the keybearers, he was ultimately revived by Young Xehanort to join Master Xehanort's new Organization XIII.
- Xemnas (Paul St. Peter) - Xehanort's nobody who once tried to create his own Kingdom Hearts from the hearts of slain Heartless in order to become a god, Xemnas has been revived from the darkness by the Unknown to join the new Organization XIII.
- Vanitas (Haley Joel Osment) - One of Xehanort's early monstrosities, he is a being of raw energy, and thrives on negative emotions to survive and create twisted minions called the "Unversed". Although he was destroyed many years ago by his good half, Ventus, Xehanort managed to revive the Unversed commander as a Sentiment to go alongside Xigbar in recruiting villains to their alliance, as well as become the 13th member of the new Organization XIII.
- Xigbar (James Patrick Stewart) - Xehanort's old minion who has been resurrected in the form of his Nobody to aid his master in recruiting an army of villains for use in conquering the realm of light. He may seem like a surfer dude, but he's very dangerous and not to be messed with, especially since he's already starting to mutate into one of Xehanort's 13 darkness clones.
- Isa (Kirk Thornton) - Lea's old friend has been corurpted fully to the darkness, and he remains loyal to his master, Xemnas, in the Syndicate/Nu Organization alliance's efforts to restart the Keyblade War. But can Lea break Isa free from Xehanort's control, or will Saix fully become just another clone of the dark lord?
- Riku Replica (David Gallagher)
The Alliance of Villain's Vale
- Maleficent (Susan Blakeslee) - The Mistress of All Evil, she is a cruel and insidious witch that will stop at nothing to reek her vengeance upon Sora.
- Pete (Jim Cummings) - Maleficent's loyal underling is still loyal to her no matter what, but now Pete's leading a sort of team of weak villains to help the rest of Maleficent's allies take over their worlds.
Villains Vale World Agents
- Captain Hook (Corey Burton) - After the events of 358/2 Days, Hook still seeks revenge against Peter Pan and capture Jane Darling.
- Gantu (Kevin Michael Richardson) - The giant, former captain of the Galactic Federation. While not entirely evil, he tends to follow his orders in a rather ruthless manner and is rather quick to pull out his blaster. He currently works for Hamsterviel.
- Commander Rourke (James Hogan) - A greedy explorer who wishes to gain the power of a long-forgotten civilization…even if it means working alongside the Heartless and betraying all who worked with him.
- Hades (James Woods) -
- Judge Claude Frollo (Corey Burton) - The mad judge has returned from the realm of darkness to seek his revenge on Sora and Riku for defeating him before.
- Cruella De Vil (April Winchell) - A greedy, rich and fur-loving lady, Cruella wants to make the perfect coat from the fur of the Dalmatian puppies. With the help of Pete, Horace, and Jasper, she has kidnapped them. The Heartless are attracted to the darkness in her heart, allowing her to command them to attack Sora and his friends
- Sa'Luk (Corey Burton) -
- Dr. Facilier (Keith David) - Known as the "Shadow Man of the Bayou", he uses voodoo magic and "Friends" from the other side in his grand scheme to become rich and powerful, the price to gain this being the souls of entire world's inhabitants.
- Yzma (Candi Milo) -
- Morgana (Candi Milo) - Ursula's crazy sister who always seemed to be second best. Her kind of magic includes ice and water.
- Sykes (Tim Curry) - A loan shark and infamous crime lord of New York, Sykes provides advanced weaponry and soldiers for Master Xehanort's plans.
- Syndrome (Jason Lee) - Syndrome, a former superhero fan now turned deadly supervillain, has teamed up with Xehanort and the Horned King in order to further his research and use the heartless to track down and destroy any Super that lands on Nomanison Island.
- Davy Jones (Bill Nighy) - An evil pirate who's cursed for all eternity to sail the seas because he ripped out his own heart. He will collect the souls of the desperate and make them his loyal henchmen.
- Zira (Nana Visitor) - Scar's conniving widow, who is consumed by years of anger and hatred directed towards Simba and the Pride Landers. Her plan is for Kovu to kill Simba and become king, thereby fulfilling her vengeance on the heroic lion.
- Madame Medusa (April Winchell) -
- Percival C. McLeach (Jonathan Freeman) -
- The Backson (Nolan North) -
The Great Demon Lords/Juubi No Yami
Although Master Xehanort and his new Organization XIII have all been destroyed by Sora and his friends, what our heroes don't realize that the Horned King has survived his destruction from the Black Cauldron, and has now begun enacting the true plan that he has kept secret from Xehanort all this time...the ultimate destruction of the multiverse with the power of the X-blade and the dark lord, Chernabog!
- Chernabog (Corey Burton) - The Demon Lord of all darkness, the Chernabog that Sora fought begore was merely just a Heartless created in his image by Xehanort. This creature is the real deal, and he's not happy for getting sealed away on Bald Mountain for 10,000 years.
- The Firebird (Hugo Weaving) - One of the original Juubi No Yami that fought during the War of Light, Firebird is Chernabog's elite second in command of the Demon Lords who takes the form of a massive bird made out of molten lava.