There could be a possiblity for an Earthworm Jim cartoon to debut on April 2010. It is a reboot in the Earthworm Jim franchise. Film Roman will produce the series.
Earthworm Jim retains the absurdist and surreal humor of the games as well as introducing its own features. Most episodes involve the series' numerous villains attempting to reclaim the super suit, rule/destroy/freeze/knock over the universe, or otherwise causing mayhem throughout the galaxy. Other problems facing Jim include returning his neighbor's eggbeater and finding a new power source after his suit is depowered. Also, the show breaks the fourth wall with characters often talking to the audience and the narrator.
Episodes begin with Earthworm Jim and Peter Puppy in some peril that has nothing to do with the main plot or the previous episodes, with little explanation of how they got into the mess. In between parts (generally before or after the commercial break), there is a short side-story, generally featuring one of the villains doing a more natural part of life, usually without any involvement from Jim. These can range anywhere from Psy-Crow opening a villainy school, Evil the Cat falling in love with a TV star, or Professor Monkey for a head attending group therapy and always ending with "and now, back to Earthworm Jim." The end of every episode involves Jim or any other character being crushed by a cow, a play on the first game of the series (in the first stage, the player launches a cow into the sky, only to have it crush the princess upon the game's ending).
- Dan Castellaneta - Earthworm Jim, Evil Jim, Jim's 4 Brains, Turns-His-Eyelids-Inside-Out Boy, Hamsternator, Grim Reaper, Jaepius: God of Puns
- Jeff Bennett - Peter Puppy, Narrator, Evil Peter, Puice Dynamo, President of the United States, Great Worm Spirit
- Charlie Adler - Professor Monkey for a Head
- Jim Cummings - Psy-Crow, Bob the Killer Goldfish, Johnny Dactyl, Walter, Zantor: Master of the Flying Toupée, Sword of Righteousness, Phlegmaphus: God of Nasal Discharge, Lower Back-Pain Man
- Edward Hibbert - Evil The Cat
- John Kassir - Snott, Henchrat
- Andrea Martin - Queen Slug-for-a-Butt, Mrs. Bleverage, The Torch Singer
- Kath Soucie - Princess What's-Her-Name, Evil Princess, Johnny's Mom, Perpsichore: Goddess of Disco
- Corey Burton - The Lord of Nightmares
- Danny Mann - Archbug
- Ben Stein - Rosebud, Dr. Houston
Storyboard Artists: Travis Cowsill, Keith Tucker, Dave Arnett, Dave Krocker, Byron Vaughns, 'Pat' Ventura, Bob Boyle, Paul Schibli, John Fountain, Larry Leichliter
Directors: Larry Leichliter, Doug TenNapel, David Perry, Paul Schibli
Writers: Doug Langdale (main writer), Steve Roberts, Jim Peterson, John Loy, 'Pat' Ventura
Overseas Animation Supervisors: Eric Goldberg (Wang Film), Larry Leichliter (Sunwoo)
Overseas Animation Studios: Wang Film Production Co. Ltd (Taiwan), Sunwoo Entertainment (South Korea)