Years ago when Peter Parker was a young boy, his parents died in a plane crash. Peter's Aunt and Uncle adopted him. Peter who is now a teenager who has a girlfriend named Gwen who works at Oscorp and is mentored by scientist Curt Connors who lost his arm in the war. One day Peter goes to visit Gwen at Oscorp when he starts to develop spider-like abilities. He also goes to meet Gwen's mentor Curt Connors for he was a colleague of his father's. After meeting Curt Connors, he helps him complete his regeneration formula. Curt Connors later tests the regeneration formula on himself regenerating his arm but the formula has a side effect turning him into a reptilian-like being known as.... the Lizard! Now Peter, still trying to learn how he got he got his powers must become Spider-man and stop the Lizard!
In the post credits, Dr. Curt Connors is in his prison cell and he is approached by a mysterious man in the shadows, being asked if he's told the real truth about Richard Parker. Replying that he hasn't, he shouts to the man that he should leave him alone as he departs from the cell like magic. Could this man be the next bad guy in the sequel or is Connors just going crazy, hinting maybe he'll be the? Lizard again soon?
Andrew Garfield - Peter Parker/Spider-Man
Emma Stone - Gwen Stacy
Rhys Ifans - Dr. Curt Connors/Lizard
Josh Emerson - Eddie Brock
Martin Sheen - Ben Parker
Sally Field - May Parker
Denis Leary - Captain George Stacy
Chris Zylka - Flash Thompson
Irrfan Khan - Dr. Ratha
Campbell Scott - Richard Parker
Embeth Davidtz - Mary Parker
Miles Elliot - Billy Connors